The San Francisco 49ers defeated the Indianapolis Colts 48-27. It was a fun game to watch, given all the points the 49ers scored. Their offense was electric and explosive in this game. They gave 49ers fans an early Christmas present with that win.

49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have officially put their playoff destiny in their own hands.

San Francisco 49ers wide receiver Jauan Jennings put on his villain mask Monday during his team’s game against the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, Ind.

The San Francisco 49ers have been one of the most injured teams thoughout the entire 2025 season. While the team will never get completely healthy, it is signif

This week’s Monday Night Football features the San Francisco 49ers visiting the Indianapolis Colts. The 49ers are 10-4, but in third place in a hyper-competitive NFC West. They have three games to move up the rankings.

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at Indianapolis.

Brock Purdy was 25 of 34 for 295 yards with one interception. Christian McCaffrey rushed 21 times for 117 yards and caught six passes for 29 yards and two scores.

Something Purdy had in common with 44-year-old Philip Rivers on Monday — mental sharpness, which came in handy in a big Monday night win.