The San Francisco 49ers still have a chance to claim the one seed in the NFC playoff bracket with a win in Week 16 over the Indianapolis Colts.

Three more teams are playoff-bound after Monday's contest between the San Francisco 49ers and the Indianapolis Colts.

The Buffalo Bills are practically a lock to make the postseason after earning their 11th win of the season on Sunday.

The NFL season continues in Week 16 when the Cleveland Browns host the Buffalo Bills on Sunday. Start time, how to watch, stream and NFL TV schedule.

The Buffalo Bills have punched their ticket to the playoffs when the 2025 NFL regular season ends in a few weeks. The Bills (11-4) beat the Cleveland Browns (3-11) in a 23-20 final on Sunday. The following day on Monday saw the Indianapolis Colts (8-7) lose 48-27 to the San Francisco 49ers at home.

The Buffalo Bills announced a devastating injury update on quarterback Josh Allen ahead of their Week 17 game.

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.

Allen completed 12 of 19 passes for just 130 yards, as Buffalo again relied heavily on the ground game. James Cook rushed 16 times for 117 yards and two touchdowns, while Ty Johnson added a rushing touchdown as well. Veteran safety Jordan Poyer stood out defensively with 11 tackles, one pass defensed and half a sack.

The Kansas City Chiefs poached quarterback Shane Buechele from the Buffalo Bills' practice squad amid a spate of injuries.