Indianapolis Colts vs San Francisco 49ers picks, predictions, win probabilities for NFL Week 16 Monday Night Football game on ...

Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 ...

Monday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Indianapolis Colts NFL ...

The Colts played it safe through the air in Rivers’s return to action in Week 15. With his passes lacking a bit of zip, it’s ...

Nine teams fell into the D range, including the runner-up to last season's Super Bowl. The majority of the six A marks have ...

Indianapolis Colts host the San Francisco 49ers for NFL Monday Night Football tonight in Week 16. MNF time, TV schedule, how ...

The San Francisco 49ers, on a four-game winning streak, try to stay hot Monday night against an Indianapolis Colts team on a ...

Philip Rivers, who came out of a five-year retirement last week to return at 44 years old, nearly matched Purdy ...

DFS millionaire Mike McClure shares his top daily fantasy picks and lineup advice for Indianapolis vs. San Francisco on ...

San Francisco aims to improve playoff position while Indianapolis fights for postseason hopes with Philip Rivers at ...

The San Francisco 49ers hit the road in Week 16 for a “Monday Night Football” showdown with veteran gunslinger Philip Rivers ...

ESPN's "Monday Night Football" matchup will have a major impact on both the AFC and NFC playoff pictures. Here's what to know ...