The San Francisco 49ers beat the Indianapolis Colts 48-27, led by Brock Purdy’s 5 TDs. Colin Cowherd asks if the now 11-4 ...

Two more wins to the 1 seed. Brock Purdy threw a career-high five touchdown passes as the Niners' offense could not be ...

San Francisco 49ers left tackle Trent Williams says he's "nowhere near done" playing football and has multiple years left ...

Week 16 was a great week for the San Francisco 49ers, who clinched a playoff berth and moved up in both the division and ...

San Francisco 49ers quarterback Brock Purdy made NFL history with the team's double-digit win over the Indianapolis Colts in ...

It's one thing to respect your elders, but the 49ers' young defensive players were taking it a little too far early on Monday ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

The Week 16 edition of "Monday Night Football" between the Indianapolis Colts (8-7) and the San Francisco 49ers (11-4) will ...

Indianapolis Colts kicker Blake Groupe makes a 51-yard field goal. San Francisco 49ers wide receiver Jauan Jennings leaps to ...

Brock Purdy, who threw a career-high five touchdowns, and the 49ers pulled away from the Colts on Monday night for a 48-27 ...